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Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

Eighteen variants recovered from specific locus mutation rate experiments involving the mutagen chlorambucil were subjected to several genetic and molecular analyses. Most mutations were found to be homozygous lethal. Because lethality is often presumptive evidence for multilocus-deletion events, 10...

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Guardat en:
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Rinchik, E M, Bangham, J W, Hunsicker, P R, Cacheiro, N L, Kwon, B S, Jackson, I J, Russell, L B
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53486/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2304907/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.4.1416
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