Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype

Dilated Cardiomyopathy (DCM) is a leading cause of sudden cardiac death characterized by impaired pump function and dilatation of cardiac ventricles. In this review we discuss various in silico approaches to elucidating the mechanisms of genetic mutations leading to DCM. The approaches covered in th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Physiol
Egile Nagusiak: Dewan, Sukriti, McCabe, Kimberly J., Regnier, Michael, McCulloch, Andrew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2017
Gaiak:
Physiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348544/
https://ncbi.nlm.nih.gov/pubmed/28352236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00151
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