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Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere
2’-deoxy-ATP (dATP) is a naturally occurring small molecule that has shown promise as a therapeutic because it significantly increases cardiac myocyte force development even at low dATP/ATP ratios. To investigate mechanisms by which dATP alters myosin crossbridge dynamics, we used Brownian dynamics...
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| Publicat a: | Arch Biochem Biophys |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7721865/ https://ncbi.nlm.nih.gov/pubmed/32956632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108582 |
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