Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere

2’-deoxy-ATP (dATP) is a naturally occurring small molecule that has shown promise as a therapeutic because it significantly increases cardiac myocyte force development even at low dATP/ATP ratios. To investigate mechanisms by which dATP alters myosin crossbridge dynamics, we used Brownian dynamics...

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Veröffentlicht in:Arch Biochem Biophys
Hauptverfasser: McCabe, Kimberly J., Aboelkassem, Yasser, Teitgen, Abigail E., Huber, Gary A., McCammon, J. Andrew, Regnier, Michael, McCulloch, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7721865/
https://ncbi.nlm.nih.gov/pubmed/32956632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108582
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