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Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation – An Integrated Multi-scale Modeling Study
Mutations in cardiac troponin C (D75Y, E59D and G159D), a key regulatory protein of myofilament contraction, have been associated with dilated cardiomyopathy (DCM). Despite reports of altered myofilament function in these mutants, the underlying molecular alterations caused by these mutations remain...
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| Publicado no: | J Phys Chem B |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5001916/ https://ncbi.nlm.nih.gov/pubmed/27133568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b01950 |
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