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Structural and Kinetic Effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI Interaction in the Cardiac Thin Filament
Residue Ser151 of cTnI is known to be phosphorylated by p21-activated kinase 3 (PAK3). It has been found that PAK3-mediated phosphorylation of cTnI induces an increase in myofilament Ca(2+) sensitivity, but the detailed mechanism is unknown. We investigated how the structural and kinetic effects med...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911129/ https://ncbi.nlm.nih.gov/pubmed/20540949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.007 |
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