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Structural and Kinetic Effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI Interaction in the Cardiac Thin Filament

Residue Ser151 of cTnI is known to be phosphorylated by p21-activated kinase 3 (PAK3). It has been found that PAK3-mediated phosphorylation of cTnI induces an increase in myofilament Ca(2+) sensitivity, but the detailed mechanism is unknown. We investigated how the structural and kinetic effects med...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ouyang, Yexin, Mamidi, Ranganath, Jayasundar, Jayant James, Chandra, Murali, Dong, Wen-Ji
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911129/
https://ncbi.nlm.nih.gov/pubmed/20540949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.06.007
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