Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

Tumor-associated macrophages (TAMs) are enriched in gliomas and help create a tumor-immunosuppressive microenvironment. A distinct M2-skewed type of macrophages makes up the majority of glioma TAMs, and these cells exhibit pro-tumor functions. Gliomas contain large hypoxic areas, and the presence of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Xiaofan, Xue, Hao, Shao, Qianqian, Wang, Jian, Guo, Xing, Chen, Xi, Zhang, Jinsen, Xu, Shugang, Li, Tong, Zhang, Ping, Gao, Xiao, Qiu, Wei, Liu, Qinglin, Li, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348338/
https://ncbi.nlm.nih.gov/pubmed/27602954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11825
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