A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway

Hypoxia induces protective autophagy in glioblastoma cells and new therapeutic avenues that target this process may improve the outcome for glioblastoma patients. Recent studies have suggested that the autophagic process is upregulated in glioblastomas in response to extensive hypoxia. Hypoxia also...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Xue, Hao, Yuan, Guang, Guo, Xing, Liu, Qinglin, Zhang, Jinsen, Gao, Xiao, Guo, Xiaofan, Xu, Shugang, Li, Tong, Shao, Qianqian, Yan, Shaofeng, Li, Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Basic Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990999/
https://ncbi.nlm.nih.gov/pubmed/27163161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1178446
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