Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

BACKGROUND: Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing of human malaria vaccines. Transgenic rodent parasites expressing genes of huma...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Phares, Timothy W., May, Anthony D., Genito, Christopher J., Hoyt, Nathan A., Khan, Farhat A., Porter, Michael D., DeBot, Margot, Waters, Norman C., Saudan, Philippe, Dutta, Sheetij
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347822/
https://ncbi.nlm.nih.gov/pubmed/28288639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-1766-3
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