Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

BACKGROUND: Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing of human malaria vaccines. Transgenic rodent parasites expressing genes of huma...

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Vydáno v:Malar J
Hlavní autoři: Phares, Timothy W., May, Anthony D., Genito, Christopher J., Hoyt, Nathan A., Khan, Farhat A., Porter, Michael D., DeBot, Margot, Waters, Norman C., Saudan, Philippe, Dutta, Sheetij
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347822/
https://ncbi.nlm.nih.gov/pubmed/28288639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-1766-3
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