Transgenic Parasites Stably Expressing Full-Length Plasmodium falciparum Circumsporozoite Protein as a Model for Vaccine Down-Selection in Mice Using Sterile Protection as an Endpoint

Circumsporozoite protein (CSP) of Plasmodium falciparum is a protective human malaria vaccine candidate. There is an urgent need for models that can rapidly down-select novel CSP-based vaccine candidates. In the present study, the mouse-mosquito transmission cycle of a transgenic Plasmodium berghei...

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Autors principals: Porter, Michael D., Nicki, Jennifer, Pool, Christopher D., DeBot, Margot, Illam, Ratish M., Brando, Clara, Bozick, Brooke, De La Vega, Patricia, Angra, Divya, Spaccapelo, Roberta, Crisanti, Andrea, Murphy, Jittawadee R., Bennett, Jason W., Schwenk, Robert J., Ockenhouse, Christian F., Dutta, Sheetij
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675977/
https://ncbi.nlm.nih.gov/pubmed/23536694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00066-13
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