Acid ceramidase is upregulated in AML and represents a novel therapeutic target

There is an urgent unmet need for new therapeutics in acute myeloid leukemia (AML) as standard therapy has not changed in the past three decades and outcome remains poor for most patients. Sphingolipid dysregulation through decreased ceramide levels and elevated sphingosine 1-phosphate (S1P) promote...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Tan, Su-Fern, Liu, Xin, Fox, Todd E., Barth, Brian M., Sharma, Arati, Turner, Stephen D., Awwad, Andy, Dewey, Alden, Doi, Kenichiro, Spitzer, Barbara, Shah, Mithun Vinod, Morad, Samy A.F., Desai, Dhimant, Amin, Shantu, Zhu, Junjia, Liao, Jason, Yun, Jong, Kester, Mark, Claxton, David F., Wang, Hong-Gang, Cabot, Myles C., Schuchman, Edward H., Levine, Ross L., Feith, David J., Loughran, Thomas P.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347763/
https://ncbi.nlm.nih.gov/pubmed/27825124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13079
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