PRIMA-1(Met) suppresses colorectal cancer independent of p53 by targeting MEK

PRIMA-1(Met) is the methylated PRIMA-1 (p53 reactivation and induction of massive apoptosis) and could restore tumor suppressor function of mutant p53 and induce p53 dependent apoptosis in cancer cells harboring mutant p53. However, p53 independent activity of PRIMA-1(Met) remains elusive. Here we r...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Tao, Zou, Yanmei, Xu, Guogang, Potter, Jane A., Taylor, Garry L., Duan, Qiuhong, Yang, Qin, Xiong, Huihua, Qiu, Hong, Ye, Dawei, Zhang, Peng, Yu, Shiying, Yuan, Xianglin, Zhu, Feng, Wang, Yihua, Xiong, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347749/
https://ncbi.nlm.nih.gov/pubmed/27806324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12940
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