Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction

Truncated tissue factor (tTF), retargeted to tumor vasculature by GNGRAHA peptide (tTF-NGR), and doxorubicin have therapeutic activity against a variety of tumors. We report on combination experiments of both drugs using different schedules. We have tested fluorescence- and HPLC-based intratumoral p...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Stucke-Ring, Janine, Ronnacker, Julian, Brand, Caroline, Höltke, Carsten, Schliemann, Christoph, Kessler, Torsten, Schmidt, Lars Henning, Harrach, Saliha, Mantke, Verena, Hintelmann, Heike, Hartmann, Wolfgang, Wardelmann, Eva, Lenz, Georg, Wünsch, Bernhard, Müller-Tidow, Carsten, Mesters, Rolf M., Schwöppe, Christian, Berdel, Wolfgang E.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347705/
https://ncbi.nlm.nih.gov/pubmed/27738341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12559
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