Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction

Truncated tissue factor (tTF), retargeted to tumor vasculature by GNGRAHA peptide (tTF-NGR), and doxorubicin have therapeutic activity against a variety of tumors. We report on combination experiments of both drugs using different schedules. We have tested fluorescence- and HPLC-based intratumoral p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Stucke-Ring, Janine, Ronnacker, Julian, Brand, Caroline, Höltke, Carsten, Schliemann, Christoph, Kessler, Torsten, Schmidt, Lars Henning, Harrach, Saliha, Mantke, Verena, Hintelmann, Heike, Hartmann, Wolfgang, Wardelmann, Eva, Lenz, Georg, Wünsch, Bernhard, Müller-Tidow, Carsten, Mesters, Rolf M., Schwöppe, Christian, Berdel, Wolfgang E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347705/
https://ncbi.nlm.nih.gov/pubmed/27738341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12559
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