Animal Safety, Toxicology, and Pharmacokinetic Studies According to the ICH S9 Guideline for a Novel Fusion Protein tTF-NGR Targeting Procoagulatory Activity into Tumor Vasculature: Are Results Predictive for Humans?

SIMPLE SUMMARY: Non-clinical safety, toxicology, and pharmacokinetic studies according to ICH guidelines with a new fusion protein tTF-NGR consisting of human truncated tissue factor (TF) and a small targeting peptide are reported. Results are compared with those of a phase I clinical dose escalatio...

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Pubblicato in:Cancers (Basel)
Autori principali: Berdel, Wolfgang E., Harrach, Saliha, Brand, Caroline, Brömmel, Kathrin, Berdel, Andrew F., Hintelmann, Heike, Schliemann, Christoph, Schwöppe, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7759859/
https://ncbi.nlm.nih.gov/pubmed/33256235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123536
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