Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)(3)-tTF

Purpose. Truncated tissue factor (tTF) fusion protein targeting tumor vasculature can induce tumor vascular thrombosis and necrosis. Here, we generated (RGD)(3)-tTF in which three arginine-glycine-aspartic (RGD) targeting integrin α (v) β (3) and tTF induce blood coagulation in tumor vessels. Method...

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Bibliografiske detaljer
Main Authors: Huang, Zheng-jie, Zhao, Yilin, Luo, Wei-yuan, You, Jun, Li, Shui-wen, Yi, Wen-cheng, Wang, Sheng-yu, Yan, Jiang-hua, Luo, Qi
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703901/
https://ncbi.nlm.nih.gov/pubmed/23861656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/637086
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