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Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis

We present a structure of the ∼650-kDa functional replisome of bacteriophage T7 assembled on DNA resembling a replication fork. A structure of the complex consisting of six domains of DNA helicase, five domains of RNA primase, two DNA polymerases, and two thioredoxin (processivity factor) molecules...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kulczyk, Arkadiusz W., Moeller, Arne, Meyer, Peter, Sliz, Piotr, Richardson, Charles C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347612/
https://ncbi.nlm.nih.gov/pubmed/28223502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701252114
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