PLCε1 regulates SDF-1α–induced lymphocyte adhesion and migration to sites of inflammation

Regulation of integrins is critical for lymphocyte adhesion to endothelium and migration throughout the body. Inside-out signaling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1). Using an RNA-mediated interference screen, we identified phospholipase Cε 1 (PLCε1) as a crucial reg...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Strazza, Marianne, Azoulay-Alfaguter, Inbar, Peled, Michael, Smrcka, Alan V., Skolnik, Edward Y., Srivastava, Shekhar, Mor, Adam
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347583/
https://ncbi.nlm.nih.gov/pubmed/28213494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612900114
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