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PLCε1 suppresses tumor growth by regulating murine T cell mobilization

Phospholipase C epsilon 1 (PLCε1) is a unique member of the phospholipase family, in that it also functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rap1. It is this function as a Rap1 GEF that gives PLCε1 an essential role in chemokine‐mediated T cell adhesion. We have uti...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Strazza, M., Adam, K., Smrcka, A. V., Lerrer, S., Mor, A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066383/
https://ncbi.nlm.nih.gov/pubmed/31867717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13409
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