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Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes. Blocking these receptors is part of the basis for β-blocker therapy for heart failure. Recent data demonst...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Nash, Craig A, Wei, Wenhui, Irannejad, Roshanak, Smrcka, Alan V
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726460/
https://ncbi.nlm.nih.gov/pubmed/31433293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48167
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