Structure–Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent

[Image: see text] Here we report the structure–activity relationship (SAR) investigations of QL-XII-47 (QL47), a compound that possesses broad-spectrum antiviral activity against dengue virus and other RNA viruses. A medicinal chemistry campaign initiated from QL47, a previously reported covalent BT...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Liang, Yanke, de Wispelaere, Melissanne, Carocci, Margot, Liu, Qingsong, Wang, Jinhua, Yang, Priscilla L., Gray, Nathanael S.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346993/
https://ncbi.nlm.nih.gov/pubmed/28337328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00008
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