Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in vivo

Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing, cross-reactive antibodies to facilitate cellular in...

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Gepubliceerd in:ACS Infect Dis
Hoofdauteurs: Li, Pi-Chun, Jang, Jaebong, Hsia, Chih-Yun, Groomes, Patrice V., Lian, Wenlong, de Wispelaere, Melissanne, Pitts, Jared D., Wang, Jinhua, Kwiatkowski, Nicholas, Gray, Nathanael S., Yang, Priscilla L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548335/
https://ncbi.nlm.nih.gov/pubmed/30608640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00322
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