A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation

Small-molecule inhibitors of translation are critical tools to study the molecular mechanisms of protein synthesis. In this study, we sought to characterize how QL47, a host-targeted, small-molecule antiviral agent, inhibits steady-state viral protein expression. We demonstrate that this small molec...

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Vydáno v:J Biol Chem
Hlavní autoři: de Wispelaere, Mélissanne, Carocci, Margot, Burri, Dominique J., Neidermyer, William J., Olson, Calla M., Roggenbach, Imme, Liang, Yanke, Wang, Jinhua, Whelan, Sean P. J., Gray, Nathanael S., Yang, Priscilla L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008383/
https://ncbi.nlm.nih.gov/pubmed/31914414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011132
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