Discovery of host-targeted covalent inhibitors of dengue virus

We report here on an approach targeting the host reactive cysteinome to identify inhibitors of host factors required for the infectious cycle of Flaviviruses and other viruses. We used two parallel cellular phenotypic screens to identify a series of covalent inhibitors, exemplified by QL-XII-47, tha...

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Bibliografske podrobnosti
izdano v:Antiviral Res
Main Authors: de Wispelaere, Mélissanne, Carocci, Margot, Liang, Yanke, Liu, Qingsong, Sun, Eileen, Vetter, Michael L., Wang, Jinhua, Gray, Nathanael S., Yang, Priscilla L.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373925/
https://ncbi.nlm.nih.gov/pubmed/28034743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.12.017
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