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Discovery of host-targeted covalent inhibitors of dengue virus
We report here on an approach targeting the host reactive cysteinome to identify inhibitors of host factors required for the infectious cycle of Flaviviruses and other viruses. We used two parallel cellular phenotypic screens to identify a series of covalent inhibitors, exemplified by QL-XII-47, tha...
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| Izdano u: | Antiviral Res |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5373925/ https://ncbi.nlm.nih.gov/pubmed/28034743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.12.017 |
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