Discovery of host-targeted covalent inhibitors of dengue virus

We report here on an approach targeting the host reactive cysteinome to identify inhibitors of host factors required for the infectious cycle of Flaviviruses and other viruses. We used two parallel cellular phenotypic screens to identify a series of covalent inhibitors, exemplified by QL-XII-47, tha...

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I publikationen:Antiviral Res
Huvudupphovsmän: de Wispelaere, Mélissanne, Carocci, Margot, Liang, Yanke, Liu, Qingsong, Sun, Eileen, Vetter, Michael L., Wang, Jinhua, Gray, Nathanael S., Yang, Priscilla L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373925/
https://ncbi.nlm.nih.gov/pubmed/28034743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.12.017
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