Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency

[Image: see text] Endoplasmic reticulum aminopeptidase 2 assists with the generation of antigenic peptides for presentation onto Major Histocompatibility Class I molecules in humans. Recent evidence has suggested that the activity of ERAP2 may contribute to the generation of autoimmunity, thus makin...

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Udgivet i:ACS Med Chem Lett
Main Authors: Mpakali, Anastasia, Giastas, Petros, Deprez-Poulain, Rebecca, Papakyriakou, Athanasios, Koumantou, Despoina, Gealageas, Ronan, Tsoukalidou, Sofia, Vourloumis, Dionisios, Mavridis, Irene M., Stratikos, Efstratios, Saridakis, Emmanuel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346973/
https://ncbi.nlm.nih.gov/pubmed/28337326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00505
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