Theory‐based pharmacokinetics and pharmacodynamics of S‐ and R‐warfarin and effects on international normalized ratio: influence of body size, composition and genotype in cardiac surgery patients

AIMS: The aims of this study are to apply a theory‐based mechanistic model to describe the pharmacokinetics (PK) and pharmacodynamics (PD) of S‐ and R‐warfarin. METHODS: Clinical data were obtained from 264 patients. Total concentrations for S‐ and R‐warfarin were measured by ultra‐high performance...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Xue, Ling, Holford, Nick, Ding, Xiao‐liang, Shen, Zhen‐ya, Huang, Chen‐rong, Zhang, Hua, Zhang, Jing‐jing, Guo, Zhe‐ning, Xie, Cheng, Zhou, Ling, Chen, Zhi‐yao, Liu, Lin‐sheng, Miao, Li‐yan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346875/
https://ncbi.nlm.nih.gov/pubmed/27763679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13157
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