DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children. To date, the expression and function of the de novo DNA methyltransferase (DNMT) 3B in RMS have not yet been investigated. Our study show fo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Megiorni, Francesca, Camero, Simona, Ceccarelli, Simona, McDowell, Heather P., Mannarino, Olga, Marampon, Francesco, Pizer, Barry, Shukla, Rajeev, Pizzuti, Antonio, Marchese, Cinzia, Clerico, Anna, Dominici, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346718/
https://ncbi.nlm.nih.gov/pubmed/27764816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12688
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