Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of signals. Energy depletion and hypoxia result in mTOR inhibition. While energy depletion inhibits mTOR through a process involving the activation of AMP-activated protein kinas...

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Bibliographic Details
Main Authors: Brugarolas, James, Lei, Kui, Hurley, Rebecca L., Manning, Brendan D., Reiling, Jan H., Hafen, Ernst, Witters, Lee A., Ellisen, Leif W., Kaelin, William G.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2004
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC534650/
https://ncbi.nlm.nih.gov/pubmed/15545625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1256804
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