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A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA

The capacity to rescue stalled replication forks (RFs) is important for the maintenance of cell viability and genome integrity. Here, we have developed a novel method for monitoring RF progression and the influence of DNA lesions on this process. The method is based on the principle that each RF is...

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Main Authors: Johansson, Fredrik, Lagerqvist, Anne, Erixon, Klaus, Jenssen, Dag
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC534636/
https://ncbi.nlm.nih.gov/pubmed/15537835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh154
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