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Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes

BACKGROUND: Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeling by stimulating proliferation and collagen synthesis of lung fibroblasts. Thi...

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Bibliographic Details
Published in:Respir Res
Main Authors: Namba, Yukiko, Togo, Shinsaku, Tulafu, Miniwan, Kadoya, Kotaro, Nagahama, Kumi Yoneda, Taka, Hikari, Kaga, Naoko, Orimo, Akira, Liu, Xiangde, Takahashi, Kazuhisa
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346259/
https://ncbi.nlm.nih.gov/pubmed/28284212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0529-6
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