Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1

BACKGROUND: Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However, unlike normal lung fibroblasts, the relatio...

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Veröffentlicht in:Respir Res
Hauptverfasser: Jin, Jin, Togo, Shinsaku, Kadoya, Kotaro, Tulafu, Miniwan, Namba, Yukiko, Iwai, Moe, Watanabe, Junko, Nagahama, Kumi, Okabe, Takahiro, Hidayat, Moulid, Kodama, Yuzo, Kitamura, Hideya, Ogura, Takashi, Kitamura, Norikazu, Ikeo, Kazuho, Sasaki, Shinichi, Tominaga, Shigeru, Takahashi, Kazuhisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558902/
https://ncbi.nlm.nih.gov/pubmed/31185973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1093-z
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