Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors

We have used total chemical synthesis to perform high-resolution dissection of the pharmacophore of a potent anti-HIV protein, the aminooxypentane oxime of [glyoxylyl(1)]RANTES(2-68), known as AOP–RANTES, of which we designed and made 37 analogs. All involved incorporation of one or more rationally...

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Detalhes bibliográficos
Main Authors: Hartley, Oliver, Gaertner, Hubert, Wilken, Jill, Thompson, Darren, Fish, Richard, Ramos, Alejandra, Pastore, Cristina, Dufour, Brigitte, Cerini, Fabrice, Melotti, Astrid, Heveker, Nikolaus, Picard, Laurent, Alizon, Marc, Mosier, Donald, Kent, Stephen, Offord, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC534511/
https://ncbi.nlm.nih.gov/pubmed/15545608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404802101
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