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Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes

The Target of Rapamycin (TOR) signalling network plays important roles in aging and disease. The AMP-activated protein kinase (AMPK) and the Gsk3 kinase inhibit TOR during stress. We performed genetic interaction screens using synthetic genetic arrays (SGA) with gsk3 and amk2 as query mutants, the l...

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Pubblicato in:Sci Rep
Autori principali: Rallis, Charalampos, Townsend, StJohn, Bähler, Jürg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345095/
https://ncbi.nlm.nih.gov/pubmed/28281664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44257
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