Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth

Target of rapamycin complex 1 (TORC1), which controls growth in response to nutrients, promotes ageing in multiple organisms. The fission yeast Schizosaccharomyces pombe emerges as a valuable genetic model system to study TORC1 function and cellular ageing. Here we exploited the combinatorial action...

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Bibliographic Details
Main Authors: Rallis, Charalampos, López-Maury, Luis, Georgescu, Teodora, Pancaldi, Vera, Bähler, Jürg
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925319/
https://ncbi.nlm.nih.gov/pubmed/24463365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20147245
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