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TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here, we analyzed the effects of rapamyc...

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Библиографические подробности
Главные авторы: Rallis, Charalampos, Codlin, Sandra, Bähler, Jürg
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798131/
https://ncbi.nlm.nih.gov/pubmed/23551936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12080
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