BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

Assessing BACE1 (β-site APP cleaving enzyme 1) knockout mice for general health and neurological function may be useful in predicting risks associated with prolonged pharmacological BACE1 inhibition, a treatment approach currently being developed for Alzheimer’s disease. To determine whether BACE1 d...

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Publicado en:Sci Rep
Autores principales: Weber, Martin, Wu, Tiffany, Meilandt, William J., Dominguez, Sara L., Solanoy, Hilda O., Maloney, Janice A., Ngu, Hai, Baca, Miriam, Kung, Chung, Lima, Lisa, Earr, Timothy K., Fleck, Daniel, Shields, Shannon D., Forrest, William F., Foreman, Oded, Warming, Søren, Watts, Ryan J., Scearce-Levie, Kimberly
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345047/
https://ncbi.nlm.nih.gov/pubmed/28281673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44249
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