EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive paralysis due to motor neuron death. Several lines of published evidence suggested that inhibition of epidermal growth factor receptor (EGFR) signaling might protect neurons from degeneration. To test th...

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Bibliografiske detaljer
Main Authors: Le Pichon, Claire E., Dominguez, Sara L., Solanoy, Hilda, Ngu, Hai, Lewin-Koh, Nicholas, Chen, Mark, Eastham-Anderson, Jeffrey, Watts, Ryan, Scearce-Levie, Kimberly
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637182/
https://ncbi.nlm.nih.gov/pubmed/23638043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062342
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