Spatial proximity to fibroblasts impacts molecular features and therapeutic sensitivity of breast cancer cells influencing clinical outcomes

Using a 3D co-culture model, we identified significant sub-type-specific changes in gene expression, metabolic, and therapeutic sensitivity profiles of breast cancer cells in contact with cancer-associated fibroblasts (CAFs). CAF-induced gene expression signatures predicted clinical outcome and immu...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Marusyk, Andriy, Tabassum, Doris P., Janiszewska, Michalina, Place, Andrew E., Trinh, Anne, Rozhok, Andrii I., Pyne, Saumyadipta, Guerriero, Jennifer L., Shu, Shaokun, Ekram, Muhammad, Ishkin, Alexander, Cahill, Daniel P., Nikolsky, Yuri, Chan, Timothy A., Rimawi, Mothaffar F., Hilsenbeck, Susan, Schiff, Rachel, Osborne, Kent C., Letai, Antony, Polyak, Kornelia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344673/
https://ncbi.nlm.nih.gov/pubmed/27671678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1457
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