Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Most human tumors are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumors have poor clinical outcomes, yet the underlying mechanism remains poorly understood. Here, we show that minor subclones of breast cancer cells expre...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Janiszewska, Michalina, Tabassum, Doris P., Castaño, Zafira, Cristea, Simona, Yamamoto, Kimiyo N., Kingston, Natalie L., Murphy, Katherine C., Shu, Shaokun, Harper, Nicholas W., Del Alcazar, Carlos Gil, Alečković, Maša, Ekram, Muhammad B., Cohen, Ofir, Kwak, Minsuk, Qin, Yuanbo, Laszewski, Tyler, Luoma, Adrienne, Marusyk, Andriy, Wucherpfennig, Kai W., Wagle, Nikhil, Fan, Rong, Michor, Franziska, McAllister, Sandra S., Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609451/
https://ncbi.nlm.nih.gov/pubmed/31263265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0346-x
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