Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three nitrile-based cysteine protease inhibitors ba...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Negl Trop Dis
Prif Awduron: Burtoloso, Antonio C. B., de Albuquerque, Sérgio, Furber, Mark, Gomes, Juliana C., Gonçalez, Cristiana, Kenny, Peter W., Leitão, Andrei, Montanari, Carlos A., Quilles, José Carlos, Ribeiro, Jean F. R., Rocha, Josmar R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344518/
https://ncbi.nlm.nih.gov/pubmed/28222138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005343
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