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Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA

Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary relaxation by activating MLCP via inhibition of RhoA pathway. In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by c...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Yu, Xuan, Zhang, Qiao, Zhao, Yan, Schwarz, Benjamin J., Stallone, John N., Heaps, Cristine L., Han, Guichun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344336/
https://ncbi.nlm.nih.gov/pubmed/28278256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173085
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