Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA

Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary relaxation by activating MLCP via inhibition of RhoA pathway. In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by c...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Yu, Xuan, Zhang, Qiao, Zhao, Yan, Schwarz, Benjamin J., Stallone, John N., Heaps, Cristine L., Han, Guichun
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2017
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344336/
https://ncbi.nlm.nih.gov/pubmed/28278256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173085
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