Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA

Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary relaxation by activating MLCP via inhibition of RhoA pathway. In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yu, Xuan, Zhang, Qiao, Zhao, Yan, Schwarz, Benjamin J., Stallone, John N., Heaps, Cristine L., Han, Guichun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344336/
https://ncbi.nlm.nih.gov/pubmed/28278256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173085
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