A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Forés, Marta, Simón-Carrasco, Lucía, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Drosten, Matthias, Barbacid, Mariano, Jiménez, Gerardo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344332/
https://ncbi.nlm.nih.gov/pubmed/28278156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006622
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