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The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

The transcriptional repressor Capicua (CIC) has emerged as an important rheostat of cell growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila, where it was shown to be inactivated by MAPK signaling downstream of the RTKs Torso and EGFR, which results in signal-dependen...

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Опубликовано в: :Cell Cycle
Главные авторы: Simón-Carrasco, Lucía, Jiménez, Gerardo, Barbacid, Mariano, Drosten, Matthias
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969551/
https://ncbi.nlm.nih.gov/pubmed/29578365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1450029
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