A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...

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Bibliografische gegevens
Gepubliceerd in:PLoS Genet
Hoofdauteurs: Forés, Marta, Simón-Carrasco, Lucía, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Drosten, Matthias, Barbacid, Mariano, Jiménez, Gerardo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344332/
https://ncbi.nlm.nih.gov/pubmed/28278156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006622
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