A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Forés, Marta, Simón-Carrasco, Lucía, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Drosten, Matthias, Barbacid, Mariano, Jiménez, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344332/
https://ncbi.nlm.nih.gov/pubmed/28278156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006622
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