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A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...
שמור ב:
| הוצא לאור ב: | PLoS Genet |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344332/ https://ncbi.nlm.nih.gov/pubmed/28278156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006622 |
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