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A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer
HMG-box proteins, including Sox/SRY (Sox) and TCF/LEF1 (TCF) family members, bind DNA via their HMG-box. This binding, however, is relatively weak and both Sox and TCF factors employ distinct mechanisms for enhancing their affinity and specificity for DNA. Here we report that Capicua (CIC), an HMG-b...
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| Publié dans: | PLoS Genet |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344332/ https://ncbi.nlm.nih.gov/pubmed/28278156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006622 |
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