Role of HGF–MET Signaling in Primary and Acquired Resistance to Targeted Therapies in Cancer

The Hepatocyte growth factor (HGF)—mesenchymal-epithelial transition (MET) pathway is deregulated in several cancers and is associated with aggressive phenotype and worse prognosis. MET, a tyrosine kinase receptor activated by HGF, plays a physiological role in embryogenesis, promoting cell growth,...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Della Corte, Carminia Maria, Fasano, Morena, Papaccio, Federica, Ciardiello, Fortunato, Morgillo, Floriana
Format: Artigo
Language:Inglês
Published: MDPI 2014
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344276/
https://ncbi.nlm.nih.gov/pubmed/28548075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines2040345
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