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Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy

Retroviral vector gene therapy is a promising approach to treating HIV-1. However, integrated vectors are mutagens with the potential to dysregulate nearby genes and cause severe adverse side effects. Leukemia has already been a documented severe adverse event in gene therapy clinical trials for the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biomedicines
Hauptverfasser: Browning, Diana L., Trobridge, Grant D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344246/
https://ncbi.nlm.nih.gov/pubmed/28424756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines4010004
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