Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.

A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Anagnou, N P, Ley, T J, Chesbro, B, Wright, G, Kitchens, C, Liebhaber, S, Nienhuis, A W, Deisseroth, A B
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1983
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534358/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6136971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.19.6051
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